Sliptin-M Tablet 50 mg+1000 mg is a combination oral anti-diabetic medicine that contains Sitagliptin 50 mg and Metformin Hydrochloride 1000 mg. It is commonly prescribed for the management of type 2 diabetes mellitus in adults when diet, exercise, or single-drug therapy alone is not sufficient to control blood sugar levels. This fixed-dose combination helps improve glycemic control through two complementary mechanisms of action.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition and Mechanism of Action

Sitagliptin belongs to a class of medicines known as DPP-4 (dipeptidyl peptidase-4) inhibitors. It works by increasing the levels of incretin hormones in the body. These hormones stimulate insulin release from the pancreas in response to meals and reduce the amount of glucose produced by the liver. Sitagliptin helps lower both fasting and post-meal blood glucose levels with a low risk of causing hypoglycemia when used alone.

Metformin Hydrochloride is a biguanide anti-diabetic agent and is considered first-line therapy for type 2 diabetes. It works primarily by decreasing hepatic glucose production (gluconeogenesis), reducing intestinal absorption of glucose, and improving insulin sensitivity in peripheral tissues such as muscles. This helps the body utilize insulin more effectively.

When combined, sitagliptin and metformin provide better blood sugar control than either medicine alone.

Indications

Sliptin-M 50 mg+1000 mg is indicated for:

• Adults with type 2 diabetes mellitus

• Patients whose blood sugar is not adequately controlled with metformin alone

• Patients already taking sitagliptin and metformin separately and requiring combination therapy

It is not used for type 1 diabetes or for treating diabetic ketoacidosis.

Dosage and Administration

The dosage is determined by the physician based on the patient’s current treatment, blood glucose levels, and kidney function. It is usually taken once or twice daily with meals to reduce gastrointestinal side effects caused by metformin. Tablets should be swallowed whole with water and not crushed or chewed.

Side Effects

Common side effects may include:

• Nausea

• Diarrhea

• Stomach discomfort

• Headache

• Upper respiratory tract infection

Metformin may rarely cause lactic acidosis, a serious but uncommon condition, especially in patients with kidney impairment. Sitagliptin may rarely cause pancreatitis or severe joint pain. Patients should seek medical attention if they experience severe abdominal pain, difficulty breathing, or unusual muscle pain.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Not recommended in patients with severe kidney disease

• Caution in liver disease

• Alcohol intake should be limited

• Kidney function should be monitored regularly

• Use during pregnancy and breastfeeding only if prescribed by a doctor

Storage

Store in a cool, dry place below 30°C, away from direct sunlight and out of reach of children.