Sovel Tablet combines Sofosbuvir 400 mg and Velpatasvir 100 mg, forming a potent, once-daily oral therapy for the treatment of chronic hepatitis C virus (HCV) infection. This direct-acting antiviral (DAA) combination is effective across all HCV genotypes (pan-genotypic) and is often used in interferon-free regimens, providing high cure rates and improved liver function.

Sofosbuvir inhibits the HCV NS5B RNA polymerase, preventing viral replication, while Velpatasvir targets the NS5A protein, blocking viral assembly and secretion. Together, they offer comprehensive suppression of HCV, enabling sustained virologic response (SVR) in most patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Sofosbuvir 400 mg
• Velpatasvir 100 mg

Mechanism of Action

• Sofosbuvir: A nucleotide analog inhibitor of NS5B polymerase that terminates viral RNA synthesis.
• Velpatasvir: NS5A inhibitor that prevents viral replication and assembly.
• Combined, they provide dual-action antiviral therapy, effectively suppressing HCV replication.

Indications

Sovel Tablet is indicated for:

• Chronic HCV infection in adults and adolescents aged 12 years and older
• All HCV genotypes (1–6)
• Treatment for treatment-naïve and previously treated patients, including those with compensated liver disease (Child-Pugh A)
• Patients with or without cirrhosis, depending on physician guidance

Dosage & Administration

• Standard dosage: 1 tablet once daily, with or without food
• Typical treatment duration: 12 weeks
• Adherence to daily dosing is critical for optimal viral clearance
• Patients with cirrhosis or prior treatment failure may require specialized dosing or extended therapy under medical supervision

Benefits

• High cure rates for all HCV genotypes
• Reduces liver inflammation and progression of liver disease
• Interferon-free regimen, minimizing systemic side effects
• Convenient once-daily oral dosing
• Improves overall liver function and long-term health

Possible Side Effects

Common side effects:

• Headache
• Fatigue
• Nausea
• Insomnia

Less common but serious side effects:

• Liver enzyme elevation
• Severe allergic reactions (rare)
• Bradycardia in patients taking amiodarone with Sofosbuvir

Precautions & Warnings

• Not recommended in severe hepatic impairment (Child-Pugh C) without specialist supervision
• Consult a physician if pregnant or breastfeeding
• Inform your doctor about all medications, especially amiodarone, to avoid interactions
• Monitor liver function tests and viral load during therapy
• Avoid alcohol and hepatotoxic drugs during treatment

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store at 20–25°C in a dry, cool place
• Protect from light and moisture
• Keep out of reach of children

Conclusion

Sovel Tablet 400 mg + 100 mg (Sofosbuvir + Velpatasvir) is a pan-genotypic, all-oral antiviral therapy for chronic hepatitis C. Its dual-action mechanism provides high cure rates, reduces liver inflammation, and offers a convenient once-daily regimen, supporting long-term liver health and preventing HCV-related complications.