Telisa-A Tablet 5 mg+80 mg is a powerful combination antihypertensive medication containing Amlodipine Besilate 5 mg, a calcium channel blocker (CCB), and Telmisartan 80 mg, an angiotensin II receptor blocker (ARB). This combination is formulated for adults who require enhanced blood pressure control that cannot be achieved with a single medication.

Amlodipine works by relaxing blood vessels, reducing vascular resistance, and improving blood flow, while Telmisartan blocks the action of angiotensin II, preventing blood vessel constriction and reducing aldosterone-mediated fluid retention. Together, they provide synergistic blood pressure reduction, offering more effective control than either agent alone. Telisa-A 5 mg+80 mg is suitable for once-daily oral administration, supporting long-term adherence and consistent therapeutic effects.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Telisa-A Tablet 5 mg+80 mg is indicated for:

• Essential hypertension in adults, particularly when monotherapy with Amlodipine or Telmisartan is insufficient

• Combination therapy to achieve target blood pressure in patients with uncontrolled hypertension

• Cardiovascular risk reduction, including lowering the risk of stroke, myocardial infarction, and other vascular complications

• Renal protection in patients with hypertension and risk of kidney damage

This formulation is intended for chronic management of blood pressure and cardiovascular protection, not for rapid relief of hypertensive crises.

Mechanism of Action

Telisa-A combines two complementary mechanisms for effective blood pressure control:

• Amlodipine Besilate (CCB): Inhibits calcium ion influx in vascular smooth muscle cells, leading to vasodilation and reduced peripheral resistance, which lowers blood pressure

• Telmisartan (ARB): Blocks angiotensin II from binding to AT1 receptors, preventing vasoconstriction and decreasing aldosterone-mediated sodium and water retention

• Synergistic effect: Dual action provides potent and sustained blood pressure reduction while improving arterial flexibility and offering cardiovascular and renal protection

By targeting multiple pathways, this combination effectively controls hypertension and reduces complications associated with high blood pressure.

Dosage and Administration

• The usual adult dose is one tablet orally once daily, with or without food

• Tablets should be swallowed whole with water

• Dose adjustments may be necessary for patients with renal or hepatic impairment

• Consistent daily use is essential for achieving and maintaining target blood pressure

• Periodic monitoring of blood pressure, kidney function, and electrolytes, particularly potassium, is recommended

Precautions and Warnings

• Pregnancy: Avoid use during the second and third trimesters due to risk of fetal harm

• Use cautiously in patients with severe kidney or liver disease

• May cause dizziness, lightheadedness, or peripheral edema, especially during initial therapy

• Patients should avoid excessive sunlight or use protection, as diuretics may increase photosensitivity

• Inform healthcare providers of all medications, including NSAIDs, potassium supplements, or other antihypertensives, to prevent drug interactions

Side Effects

Telisa-A Tablet 5 mg+80 mg is generally well tolerated. Common side effects include:

• Dizziness, headache, or fatigue

• Mild swelling of the ankles or feet (peripheral edema)

• Gastrointestinal discomfort such as nausea or upset stomach

• Rare side effects: hypotension, electrolyte imbalance, kidney function changes

• Very rare: allergic reactions or severe cardiovascular events

Seek immediate medical attention if severe dizziness, swelling, shortness of breath, or unusual symptoms occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.

Telisa-A Tablet 5 mg+80 mg offers effective once-daily blood pressure control with dual mechanisms, providing enhanced cardiovascular and renal protection for adults requiring combination therapy.