Tofara Tablet 5 mg contains Tofacitinib, an oral Janus kinase (JAK) inhibitor designed to manage autoimmune and inflammatory conditions. By selectively inhibiting JAK enzymes, Tofacitinib interferes with the signaling pathways that drive inflammation and immune system overactivity.

Tofara is primarily used in adults with conditions such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis, providing relief from joint pain, swelling, stiffness, and other symptoms associated with chronic inflammation.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Tofara Tablet is indicated for:

• Moderate to severe rheumatoid arthritis in adults with inadequate response to conventional therapy
• Active psoriatic arthritis for symptom control and joint protection
• Ulcerative colitis in adults with moderate to severe disease activity
• Reduction of inflammation and prevention of disease progression in autoimmune disorders

Mechanism of Action

Tofacitinib works by blocking JAK enzymes (JAK1 and JAK3):

• Interrupts the JAK-STAT signaling pathway
• Reduces production of pro-inflammatory cytokines
• Limits immune system overactivation, decreasing joint and tissue inflammation
• Improves symptoms such as pain, swelling, and stiffness

By targeting these pathways, Tofara helps control autoimmune activity without broadly suppressing the immune system.

Dosage and Administration

• Recommended dose: 5 mg orally twice daily, or as prescribed by a healthcare professional
• Can be taken with or without food
• Swallow tablets whole with water
• Dose adjustments may be needed in patients with kidney or liver impairment
• Regular monitoring by a physician is required to track disease activity and potential side effects

Benefits

• Reduces joint pain, swelling, and stiffness
• Improves mobility and physical function
• Controls inflammation in autoimmune diseases
• May slow disease progression and joint damage
• Convenient oral therapy for long-term disease management

Side Effects

Common side effects may include:

• Upper respiratory tract infections
• Headache
• Diarrhea or gastrointestinal discomfort
• Elevated liver enzymes or lipid levels
• Mild anemia

Serious but rare side effects:

• Serious infections (e.g., tuberculosis, pneumonia)
• Blood clots (deep vein thrombosis or pulmonary embolism)
• Liver toxicity or liver function abnormalities
• Malignancies (rare)

Seek medical attention immediately if you experience signs of infection, unexplained bruising, or severe fatigue.

Precautions and Warnings

• Not recommended in patients with active serious infections
• Vaccinations should be up to date before starting therapy
• Regular monitoring of blood counts, liver function, and lipids is essential
• Avoid live vaccines during treatment
• Pregnancy and breastfeeding: consult a healthcare professional before use
• Use cautiously in patients with a history of blood clots or cardiovascular risk

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Tofacitinib may interact with:

• Strong CYP3A4 inhibitors or inducers (affects drug levels)
• Immunosuppressants (increased infection risk)
• Other medications affecting blood counts or liver function

Always inform your healthcare provider of all medications, supplements, and herbal products being taken.

Storage

• Store below 25°C in a dry, cool place
• Protect from light and moisture
• Keep out of reach of children
• Do not use after the expiration date.