Trio Inhalation Capsule is a triple-combination therapy containing Vilanterol Trifenatate, Fluticasone Furoate, and Umeclidinium Bromide, formulated for the treatment of chronic obstructive pulmonary disease (COPD) and severe asthma in adults. This combination targets multiple pathways in the airways to provide bronchodilation, anti-inflammatory effects, and improved lung function, helping patients breathe more easily and reduce exacerbations.

• Vilanterol Trifenatate: A long-acting beta-2 agonist (LABA) that relaxes airway muscles, improving airflow.
• Fluticasone Furoate: An inhaled corticosteroid (ICS) that reduces airway inflammation and swelling.
• Umeclidinium Bromide: A long-acting muscarinic antagonist (LAMA) that prevents airway constriction and enhances bronchodilation.

This inhalation capsule delivers convenient, once-daily therapy for optimal disease control and better quality of life.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Trio Inhalation Capsule is indicated for:

• Maintenance treatment of chronic obstructive pulmonary disease (COPD)
• Symptomatic patients with severe asthma requiring combination therapy
• Patients with a history of frequent exacerbations despite standard dual therapy
• Improving lung function, reducing shortness of breath, and preventing flare-ups

Mechanism of Action

The three active components work synergistically:

• Vilanterol Trifenatate (LABA): Stimulates beta-2 receptors in airway smooth muscles, causing bronchodilation and reducing airway resistance.
• Fluticasone Furoate (ICS): Suppresses airway inflammation, decreases mucus production, and minimizes airway hyperreactivity.
• Umeclidinium Bromide (LAMA): Blocks muscarinic receptors, preventing bronchoconstriction and enhancing airflow.

Together, this triple therapy improves respiratory function, reduces symptoms, and helps prevent acute exacerbations.

Dosage and Administration

• Recommended dose: 1 inhalation capsule once daily, preferably at the same time each day
• Use with the prescribed dry powder inhaler (DPI) device
• Do not swallow the capsule; it must be inhaled using the inhaler
• Rinse mouth after inhalation to reduce risk of oral thrush from the corticosteroid
• Not intended for acute relief of sudden breathing difficulties

Benefits

• Improves lung function and breathing capacity
• Reduces frequency and severity of COPD and asthma exacerbations
• Provides once-daily convenient dosing for better adherence
• Targets multiple mechanisms: bronchodilation, anti-inflammatory action, and airway relaxation
• Enhances quality of life and physical activity tolerance

Side Effects

Common side effects may include:

• Throat irritation or hoarseness
• Oral candidiasis (fungal infection)
• Cough or dry mouth
• Headache or mild dizziness

Rare but serious side effects:

• Paradoxical bronchospasm (sudden worsening of breathing)
• Increased heart rate or palpitations
• Severe allergic reactions

Seek medical attention if severe breathing difficulties, allergic reactions, or heart-related symptoms occur.

Precautions and Warnings

• Not for use as a rescue inhaler for acute asthma or COPD attacks
• Use cautiously in patients with cardiovascular disease, glaucoma, or urinary retention
• Monitor for signs of adrenal suppression or pneumonia in chronic corticosteroid use
• Pregnancy and breastfeeding: only use if clearly needed under physician supervision
• Follow the inhaler technique instructions carefully to ensure effective drug delivery

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Trio may interact with:

• Other beta-agonists (may increase heart rate or blood pressure)
• Strong CYP3A4 inhibitors (may increase corticosteroid levels)
• Anticholinergic medications (additive effects)

Inform your healthcare provider about all medications and supplements before starting therapy.

Storage

• Store below 30°C in a dry place
• Keep capsules in the blister pack until use
• Protect from moisture and direct sunlight
• Keep out of reach of children
• Do not use after the expiration date.