Triocim 50 ml is indicated for the treatment of the following infections when caused by susceptible organisms:

• Upper Respiratory Tract Infections (URTI):
  Including otitis media and other URTIs where the causative organism is resistant to commonly used antibiotics or where treatment failure may carry significant risk

• Lower Respiratory Tract Infections:
  Such as bronchitis

• Urinary Tract Infections (UTI):
  Including cystitis, cystourethritis, and pyelonephritis

• Typhoid fever (according to recommended dosing)

Clinical efficacy has been demonstrated against common pathogens such as Streptococcus pneumoniae, Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Klebsiella species, Haemophilus influenzae (beta-lactamase positive and negative), Moraxella catarrhalis, and Enterobacter species.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Third Generation Cephalosporins

Pharmacology

Cefixime is a third-generation semisynthetic cephalosporin antibiotic intended for oral administration. It exerts a bactericidal effect by inhibiting bacterial cell wall synthesis. Due to its high stability against beta-lactamase enzymes, Cefixime remains effective against many organisms resistant to penicillins and some cephalosporins. Oral absorption is approximately 40–50% and is not significantly affected by food intake.

Dosage and Administration

• Children (6 months or older):
  Recommended dose is 8 mg/kg/day, administered as a single dose or in two divided doses
  General daily dosing guide:

  • 6 months to 1 year: 75 mg (3.75 ml) daily

  • 1–4 years: 100 mg (5 ml) daily

  • 5–10 years: 200 mg (10 ml) daily

  • 11–12 years: 300 mg daily

• Typhoid fever:
  5 mg/kg body weight twice daily for 10–14 days

• Children weighing over 50 kg or older than 10 years:
  200–400 mg daily, similar to adult dosing

• Children under 6 months:
  Safety and efficacy have not been established

The usual course of treatment is 7 days, which may be extended up to 14 days depending on infection severity.

Dosage in Renal Impairment

• Normal dosing may be used if creatinine clearance is ≥20 ml/min

• If creatinine clearance is <20 ml/min, the dose should not exceed 200 mg once daily

• Same recommendation applies to patients on hemodialysis or peritoneal dialysis

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

As with other cephalosporins, increased prothrombin time has been observed in some patients. Caution is advised when used concurrently with anticoagulant therapy.

Contraindications

Triocim 50 ml is contraindicated in patients with known hypersensitivity to cephalosporin antibiotics.

Side Effects

Triocim 50 ml is generally well tolerated. Most adverse reactions are mild and self-limiting.

• Gastrointestinal: Diarrhea, stool changes, nausea, abdominal pain, dyspepsia, vomiting, flatulence; rare cases of pseudomembranous colitis

• Central Nervous System: Headache, dizziness

• Hypersensitivity: Rash, pruritus, urticaria, drug fever, arthralgia

• Hematological: Thrombocytopenia, leukopenia, eosinophilia (rare and reversible)

• Others: Transient changes in liver and renal function tests, genital pruritus, vaginitis

Pregnancy and Lactation

There are no adequate and well-controlled studies in pregnant women. Triocim 50 ml should be used during pregnancy only if clearly needed. It is not known whether Cefixime is excreted in human milk; therefore, caution should be exercised when administered to nursing mothers.

Precautions and Warnings

• Use cautiously in patients with a history of penicillin hypersensitivity due to possible cross-reactivity

• Discontinue immediately if allergic reactions occur

• Administer with caution in patients with severe renal impairment

• Prolonged use may result in overgrowth of non-susceptible organisms, including Clostridium difficile

Overdose

No specific antidote is available. Gastric lavage may be considered if appropriate. Cefixime is not significantly removed by hemodialysis or peritoneal dialysis.

Storage Conditions

Store below 30°C, protected from light and moisture. Keep out of the reach of children.