Trum 3 Injection 250 mg/vial contains Ceftazidime Pentahydrate 250 mg, a third-generation cephalosporin antibiotic with broad-spectrum activity against Gram-negative and some Gram-positive bacteria. It is highly effective in treating serious bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, and septicemia.

Ceftazidime works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. Trum 3 Injection is particularly valuable in hospital settings for managing severe infections caused by resistant bacteria, including Pseudomonas aeruginosa, due to its potent bactericidal activity.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Ceftazidime Pentahydrate 250 mg per vial

Mechanism of Action

Ceftazidime, the active ingredient in Trum 3 Injection, belongs to the cephalosporin class of β-lactam antibiotics:

1. Inhibition of bacterial cell wall synthesis – Ceftazidime binds to penicillin-binding proteins (PBPs) in bacterial cell walls, disrupting peptidoglycan cross-linking.

2. Bactericidal effect – Weakening the cell wall causes bacterial lysis and death, effectively eliminating the infection.

3. Broad-spectrum activity – Active against many Gram-negative organisms, including Pseudomonas species, and some Gram-positive bacteria, making it versatile for treating mixed infections.

4. Stability against β-lactamases – Resistant to many bacterial β-lactamases, which enhances its efficacy against resistant bacterial strains.

Through these mechanisms, Trum 3 Injection rapidly controls bacterial proliferation and prevents infection progression.

Indications

Trum 3 Injection 250 mg/vial is indicated for the treatment of:

• Respiratory tract infections – pneumonia, bronchitis, and severe lung infections

• Urinary tract infections – complicated or uncomplicated infections

• Skin and soft tissue infections – cellulitis, abscesses, and wound infections

• Intra-abdominal infections – peritonitis and secondary infections

• Septicemia and bloodstream infections – especially in hospitalized patients

• Bone and joint infections – osteomyelitis and septic arthritis

It is suitable for use in adults, children, and immunocompromised patients under physician supervision.

Dosage and Administration

• Dosage depends on the severity of infection, patient age, and kidney function.

• Typically administered intravenously (IV) or intramuscularly (IM) after reconstitution.

• Adults: Commonly 250 mg to 2 g every 8 to 12 hours, adjusted per infection severity.

• Pediatric patients: Dose is calculated based on body weight.

• Care must be taken to follow proper reconstitution and aseptic technique.

• Monitor renal function during prolonged therapy and adjust dosage in patients with kidney impairment.

Benefits

• Rapid and effective bactericidal activity against a broad spectrum of bacteria

• Particularly effective against resistant Gram-negative infections

• Can be used in serious, hospital-acquired, or complicated infections

• Versatile administration via IV or IM routes

• Supports both monotherapy and combination therapy for severe infections

Precautions

• Use with caution in patients with a history of penicillin or cephalosporin allergy.

• Monitor for renal impairment; dosage adjustment may be required.

• Avoid prolonged use to prevent antibiotic resistance or secondary infections.

• Observe for signs of superinfection with prolonged therapy.

• Pregnancy and lactation: Use only if clearly needed and under medical supervision.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects:

• Local reactions at injection site: pain, redness, or swelling

• Gastrointestinal disturbances: nausea, vomiting, diarrhea

• Headache or dizziness

Serious side effects requiring medical attention:

• Allergic reactions: rash, itching, anaphylaxis

• Severe diarrhea or colitis due to Clostridium difficile

• Blood disorders: neutropenia or thrombocytopenia (rare)

Storage

• Store below 25°C in a cool, dry place

• Protect from light and moisture

• Keep the vial tightly closed until use

• Keep out of reach of children

Trum 3 Injection 250 mg/vial is a potent cephalosporin antibiotic for the treatment of severe bacterial infections, offering broad-spectrum coverage and rapid bactericidal activity under careful medical supervision.