Turbocef 125 mg/5 ml is indicated for the treatment of infections caused by susceptible bacteria, including:

• Upper respiratory tract infections

  • Pharyngitis and tonsillitis caused by Streptococcus pyogenes

  • Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae (non β-lactamase producing strains)

• Ear infections

  • Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (β-lactamase producing strains), or Streptococcus pyogenes

• Lower respiratory tract infections

  • Pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae (including β-lactamase producing strains), Klebsiella species, Staphylococcus aureus, Streptococcus pyogenes, or Escherichia coli

  • Acute bacterial exacerbation of chronic bronchitis

  • Secondary bacterial infections of acute bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae, or Haemophilus parainfluenzae

• Skin and soft tissue infections

  • Caused by Staphylococcus aureus (including β-lactamase producing strains) or Streptococcus pyogenes

• Urinary tract infections

  • Caused by Escherichia coli or Klebsiella pneumoniae

• Bone and joint infections

  • Caused by Staphylococcus aureus

• Other infections

  • Gonorrhoea caused by penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae

  • Early Lyme disease (erythema migrans) caused by Borrelia burgdorferi

Pharmacology

Cefuroxime inhibits bacterial cell wall synthesis, leading to rapid bacterial cell death. It is highly resistant to degradation by β-lactamase enzymes, making it effective against many ampicillin- and amoxicillin-resistant organisms.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

Paediatric Patients (3 months–12 years):

• Pharyngitis/Tonsillitis: 20 mg/kg/day in two divided doses for 5–10 days

• Acute otitis media: 30 mg/kg/day in two divided doses for 10 days

• Acute bacterial maxillary sinusitis: 30 mg/kg/day in two divided doses for 10 days

• Impetigo: 30 mg/kg/day in two divided doses for 10 days

Dosage should be adjusted according to the severity of infection and the child’s clinical condition.

Administration

Freshly reconstituted suspension is recommended. After reconstitution, the suspension maintains potency for up to 24 hours at room temperature or up to 48 hours when refrigerated at 5°C.

Contraindications

Turbocef 125 mg/5 ml is contraindicated in patients with known hypersensitivity to cefuroxime or other cephalosporins.

Side Effects

Adverse effects are generally mild and transient and may include:

• Gastrointestinal disturbances

• Skin rashes

• Overgrowth of non-susceptible organisms such as Candida with prolonged use

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

No clinically significant or potentially hazardous drug interactions have been reported.

Pregnancy and Lactation

Cefuroxime is classified as US FDA Pregnancy Category B. It should be used during pregnancy only if clearly needed. Cefuroxime is excreted in breast milk; therefore, caution is advised when administered to nursing mothers.

Precautions and Warnings

• Use with caution in patients with a history of colitis

• Caution is required when used with potent diuretics

• Although generally safe in penicillin-allergic patients, cross-reactivity has been reported

Storage Conditions

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.