Turbocef 500 mg contains Cefuroxime, a second-generation cephalosporin antibiotic known for its broad-spectrum bactericidal activity. It is effective against a wide variety of Gram-positive and Gram-negative bacteria, including many β-lactamase–producing strains. Turbocef 500 mg is commonly prescribed for moderate to severe bacterial infections involving the respiratory tract, skin, urinary tract, bones, joints, and other systemic infections.

Therapeutic Class

Second Generation Cephalosporins

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Turbocef 500 mg is indicated for the treatment of infections caused by susceptible organisms, including:

• Upper respiratory tract infections

  • Pharyngitis and tonsillitis caused by Streptococcus pyogenes

  • Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae (non β-lactamase producing strains)

• Ear infections

  • Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (β-lactamase producing strains), or Streptococcus pyogenes

• Lower respiratory tract infections

  • Community-acquired pneumonia

  • Acute bacterial exacerbation of chronic bronchitis

  • Secondary bacterial infections of acute bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae (β-lactamase negative strains), or Haemophilus parainfluenzae

• Skin and soft tissue infections

  • Caused by Staphylococcus aureus (including β-lactamase producing strains) or Streptococcus pyogenes

• Urinary tract infections

  • Caused by Escherichia coli or Klebsiella pneumoniae

• Bone and joint infections

  • Caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains)

• Sexually transmitted infections

  • Gonorrhoea caused by penicillinase-producing and non-penicillinase producing strains of Neisseria gonorrhoeae

• Other infections

  • Early Lyme disease (erythema migrans) caused by Borrelia burgdorferi

  • Multidrug-resistant typhoid fever

Pharmacology

Cefuroxime acts by inhibiting bacterial cell wall synthesis, resulting in cell death. It demonstrates high stability against bacterial β-lactamase enzymes, making it effective against many ampicillin- and amoxicillin-resistant organisms.

Dosage and Administration

Oral (Tablet or Suspension)

Adolescents and Adults (≥13 years):

• Pharyngitis/Tonsillitis: 250 mg twice daily for 5–10 days

• Acute maxillary sinusitis: 250 mg twice daily for 10 days

• Acute exacerbation of chronic bronchitis: 250–500 mg twice daily for 10 days

• Secondary bacterial infection of acute bronchitis: 250–500 mg twice daily for 5–10 days

• Uncomplicated skin and soft tissue infections: 250–500 mg twice daily for 10 days

• Uncomplicated urinary tract infections: 250 mg twice daily for 7–10 days

• Gonorrhoea: 1000 mg as a single dose

• Community-acquired pneumonia: 250–500 mg twice daily for 5–10 days

• MDR typhoid fever: 500 mg twice daily for 10–14 days

• Early Lyme disease: 500 mg twice daily for 20 days

Paediatric Patients (3 months–12 years):

• Pharyngitis/Tonsillitis: 20 mg/kg/day in two divided doses

• Acute otitis media: 30 mg/kg/day in two divided doses

• Acute bacterial sinusitis: 30 mg/kg/day in two divided doses

• Impetigo: 30 mg/kg/day in two divided doses

Dosage should be adjusted based on severity of infection and clinical response.

Contraindications

Turbocef 500 mg is contraindicated in patients with known hypersensitivity to cefuroxime or other cephalosporin antibiotics.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Cefuroxime is generally well tolerated. Reported side effects are usually mild and transient and may include:

• Gastrointestinal disturbances

• Skin rashes

• Overgrowth of non-susceptible organisms such as Candida with prolonged use

Drug Interactions

No clinically significant or potentially hazardous drug interactions have been reported.

Pregnancy and Lactation

Cefuroxime is classified as US FDA Pregnancy Category B. It should be used during pregnancy only if clearly needed. Cefuroxime is excreted in human milk; therefore, caution should be exercised when administered to nursing mothers.

Precautions and Warnings

• Use with caution in patients with a history of colitis

• Caution is advised when used concurrently with potent diuretics

• Although generally safe in penicillin-allergic patients, cross-reactivity has been reported

Storage Conditions

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.