Uroben XR 50 mg is a specialized medication for the symptomatic treatment of overactive bladder (OAB) syndrome in adults. It effectively manages urgency, increased micturition frequency, and urgency incontinence, helping patients achieve better urinary control and improved quality of life.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• BPH (Benign Prostatic Hyperplasia)

• Urinary Retention

• Urinary Incontinence

Indications

Uroben XR 50 mg is indicated for:

• Symptomatic relief of urgency

• Reduction of frequent urination

• Management of urgency incontinence in adult patients with overactive bladder (OAB)

Pharmacology / Mode of Action

Uroben XR 50 mg is a potent and selective beta-3 adrenoceptor agonist. It works by:

• Relaxing bladder smooth muscle to increase bladder capacity

• Increasing cyclic AMP (cAMP) levels in bladder tissue

• Reducing non-voiding contractions and enhancing urine storage

• Acting selectively on beta-3 receptors during the bladder storage phase, without affecting normal voiding

This dual mechanism improves urine storage both directly on the bladder smooth muscle and via the sensory nervous system, leading to increased bladder capacity and reduced urgency.

Dosage & Administration

• Adults (including elderly): Start with 25 mg once daily, alone or with solifenacin succinate 5 mg. Based on response and tolerability, increase to 50 mg once daily.

• Renal/Hepatic Impairment: Maximum 25 mg daily for severe renal impairment or moderate hepatic impairment. Not recommended in end-stage renal disease or severe hepatic impairment.

• Pediatric Use: Safety and efficacy not established for patients under 18 years.

• Administration: Swallow whole with water, with or without food. Do not chew, crush, or divide.

Contraindications

• Hypersensitivity to Uroben XR 50 mg or excipients

• Severe uncontrolled hypertension (systolic ≥180 mmHg or diastolic ≥110 mmHg)

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Commonly reported side effects include:

• Tachycardia

• Urinary tract infections (UTIs)

Less common but serious effects:

• Atrial fibrillation (0.2%)

Precautions & Warnings

• Use with caution in patients with bladder outlet obstruction or those taking antimuscarinic medications for OAB.

• Blood pressure monitoring recommended, especially in hypertensive patients.

• Use caution in patients with QT prolongation.

• Dose adjustments required for renal or hepatic impairment when used with CYP3A inhibitors.

Pregnancy & Lactation

• Not recommended during pregnancy or in women planning pregnancy.

• Likely excreted in human milk; should not be used during breastfeeding.

Overdose

Symptoms may include palpitations, increased pulse, and elevated blood pressure. Treatment is symptomatic and supportive, with monitoring of pulse, blood pressure, and ECG.

Storage

• Store in a cool, dry place protected from light.