Zidicef Injection 250 mg/vial contains Ceftazidime Pentahydrate, a third-generation cephalosporin antibiotic used for the treatment of a wide range of serious bacterial infections. It is commonly administered in hospital settings for infections caused by susceptible Gram-negative organisms, including Pseudomonas aeruginosa. Zidicef works by inhibiting bacterial cell wall synthesis, leading to the destruction of bacteria.

This injectable formulation is suitable for moderate to severe infections where rapid and reliable antibiotic action is required.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Zidicef Injection 250 mg/vial is indicated for:

• Lower respiratory tract infections (pneumonia, bronchitis)
• Urinary tract infections (complicated and uncomplicated)
• Skin and soft tissue infections
• Bone and joint infections
• Intra-abdominal infections (in combination therapy if required)
• Septicemia (bloodstream infections)
• Meningitis caused by susceptible organisms

Mechanism of Action

Ceftazidime is a beta-lactam antibiotic that works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), preventing the formation of peptidoglycan layers essential for bacterial cell wall strength. This leads to weakening and eventual lysis of the bacteria.

It is particularly effective against Gram-negative organisms, including Pseudomonas species.

Dosage and Administration

• Administered via intravenous (IV) or intramuscular (IM) injection under medical supervision
• Dosage depends on infection severity, patient age, and renal function
• Reconstitution must be done using appropriate sterile diluent before administration
• Dose adjustments are required in patients with renal impairment
• Treatment duration is determined by clinical response

Side Effects

Common side effects may include:

• Injection site pain or inflammation
• Diarrhea
• Rash
• Nausea and vomiting

Serious side effects may include:

• Severe allergic reactions (anaphylaxis)
• Clostridioides difficile-associated diarrhea
• Blood disorders (e.g., leukopenia, thrombocytopenia)
• Seizures (rare, especially in renal impairment)

Immediate medical attention is required if severe reactions occur.

Precautions and Warnings

• Use cautiously in patients with a history of penicillin or cephalosporin allergy
• Dose adjustment is necessary in renal impairment
• Prolonged use may lead to superinfection or antibiotic resistance
• Monitor kidney function and blood counts during therapy
• Use during pregnancy or breastfeeding only if clearly needed

Drug Interactions

Zidicef Injection may interact with:

• Aminoglycoside antibiotics (increased risk of kidney toxicity)
• Loop diuretics
• Chloramphenicol (possible antagonistic effect)
• Anticoagulants (may enhance bleeding risk)

Always inform the healthcare provider about all medications being used.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store below 30°C in a dry place
• Protect from light and moisture
• Reconstituted solution should be used immediately or as directed
• Keep out of reach of children

Conclusion

Zidicef Injection 250 mg/vial (Ceftazidime Pentahydrate) is a powerful broad-spectrum antibiotic used for serious bacterial infections, particularly those caused by Gram-negative organisms. When administered under proper medical supervision, it provides effective infection control and supports rapid clinical recovery.