Zopilone Tablet 2 mg contains Eszopiclone, a non-benzodiazepine hypnotic used for the treatment of insomnia. It helps patients fall asleep faster, reduces nighttime awakenings, and improves overall sleep quality. Its rapid onset and intermediate duration of action make it suitable for both sleep initiation and maintenance, allowing patients to achieve restorative sleep without significant next-day drowsiness.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Non-Benzodiazepine Hypnotics (Cyclopyrrolone class)

Indications

Zopilone 2 mg is indicated for:

• Short-term and long-term management of insomnia

• Difficulty falling asleep (sleep onset insomnia)

• Difficulty staying asleep (sleep maintenance insomnia)

• Improving overall sleep quality and daytime functioning

Pharmacology

Eszopiclone, the active component of Zopilone, selectively binds to the GABA-A receptor complex at the benzodiazepine binding site, enhancing the inhibitory action of GABA in the central nervous system. This results in sedation, reduction of sleep latency, and prolonged total sleep time. Unlike traditional benzodiazepines, Eszopiclone has minimal muscle relaxant and anticonvulsant activity, reducing the risk of dependence and next-day cognitive impairment when used appropriately.

Dosage and Administration

• Adults: 1–3 mg orally immediately before bedtime.

  • Typical starting dose: 2 mg

  • Maximum recommended dose: 3 mg

• Elderly or debilitated patients: 1 mg starting dose is recommended due to increased sensitivity and slower metabolism

• Administration Notes:

  • Take immediately before going to bed

  • Ensure at least 7–8 hours of sleep before planned awakening

  • Tablets should be swallowed whole with water; avoid crushing or chewing

    রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• CNS depressants, alcohol, antihistamines, and other sedative-hypnotics may increase sedation and risk of respiratory depression

• Caution when used with drugs metabolized via CYP3A4, as Eszopiclone metabolism may be affected

• Concomitant use with strong CYP3A4 inhibitors may require dose adjustment

Contraindications

• Known hypersensitivity to Eszopiclone or any tablet excipients

• Severe hepatic impairment

• History of complex sleep behaviors (sleepwalking, sleep-driving) related to hypnotic use

• Pregnancy and lactation unless prescribed by a physician

Side Effects

Common:

• Drowsiness, dizziness, headache, unpleasant taste, dry mouth

• Mild gastrointestinal disturbances

Rare:

• Sleep-related complex behaviors (e.g., sleep-driving, sleep-eating)

• Allergic reactions or hallucinations

Precautions & Warnings

• May cause next-day drowsiness, impaired alertness, and motor coordination

• Use caution when driving or operating machinery

• Gradual dose titration is recommended to minimize side effects

• Avoid abrupt discontinuation; rebound insomnia may occur

• Not recommended for patients with severe respiratory impairment or sleep apnea without medical supervision

Overdose

Symptoms: Excessive sedation, confusion, impaired coordination, respiratory depression
Management: Supportive care, monitoring of vital signs, and symptomatic treatment

Pregnancy & Lactation

• Category C: Use only if potential benefits outweigh risks

• Not recommended during breastfeeding due to limited safety data

Storage Conditions

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.