A-Fenac Suppository 12.5 mg contains Diclofenac Sodium, a well-established nonsteroidal anti-inflammatory drug (NSAID) used for the relief of pain, inflammation, and fever. This low-dose rectal formulation is particularly suitable for pediatric patients and for individuals who are unable to take oral medications due to nausea, vomiting, swallowing difficulties, or post-operative conditions. Rectal administration allows effective systemic absorption while minimizing gastrointestinal irritation associated with oral NSAIDs.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

A-Fenac Suppository 12.5 mg is indicated for the management of mild to moderate pain and inflammatory conditions, including:

• Fever and pain associated with infections

• Post-operative pain

• Pain following minor surgical or diagnostic procedures

• Musculoskeletal pain

• Dental pain

• Ear, nose, and throat inflammatory conditions

• Pain associated with trauma

It is especially useful in children where oral administration is not feasible.

Therapeutic Class

Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Pharmacology

Diclofenac Sodium works by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased synthesis of prostaglandins. Prostaglandins play a key role in mediating pain, inflammation, and fever. By reducing prostaglandin production, diclofenac effectively alleviates these symptoms.

Following rectal administration, diclofenac is absorbed through the rectal mucosa into systemic circulation. Although absorption is slightly slower compared to intramuscular injection, it provides reliable and sustained therapeutic levels. Diclofenac is highly protein-bound and undergoes hepatic metabolism, with metabolites excreted mainly via the kidneys.

Mechanism of Action

A-Fenac Suppository reduces pain and inflammation by blocking the biochemical pathways responsible for prostaglandin formation at sites of tissue injury. This results in effective analgesic, anti-inflammatory, and antipyretic action.

Dosage and Administration

• Children: Dose should be determined based on age, body weight, and clinical condition, as prescribed by a physician

• Adults: May be used in selected cases when oral administration is unsuitable

The suppository should be inserted rectally, preferably after bowel evacuation. Hands should be washed before and after administration. Use should be limited to the shortest duration necessary to control symptoms.

Drug Interactions

Diclofenac may interact with other NSAIDs, corticosteroids, anticoagulants, antiplatelet agents, antihypertensive drugs, lithium, methotrexate, and diuretics. Concurrent use may increase the risk of gastrointestinal bleeding or renal impairment.

Contraindications

A-Fenac Suppository is contraindicated in patients with:

• Hypersensitivity to diclofenac or other NSAIDs

• History of NSAID-induced asthma or allergic reactions

• Active peptic ulcer disease or gastrointestinal bleeding

• Severe hepatic, renal, or cardiac dysfunction

• Inflammatory diseases of the rectum or anus

Side Effects

Possible side effects include:

• Rectal irritation or discomfort

• Nausea, vomiting, or abdominal pain

• Headache or dizziness

Serious adverse effects such as gastrointestinal bleeding or allergic reactions are rare at low doses but may occur with prolonged use.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Pregnancy and Lactation

Diclofenac should be avoided during pregnancy, particularly in the third trimester. Use during breastfeeding should be under medical supervision.

Storage Conditions

Store below 30°C in a cool, dry place. Protect from heat and light. Keep out of reach of children.