Avloclav Injection is a broad-spectrum antibiotic containing Amoxicillin 1 gm and Clavulanic Acid 200 mg per 20 ml. This combination belongs to the beta-lactam class of antibiotics and is designed to treat bacterial infections resistant to plain amoxicillin. Amoxicillin works by inhibiting bacterial cell wall synthesis, while Clavulanic Acid blocks beta-lactamase enzymes produced by some bacteria that would otherwise destroy amoxicillin. This synergistic effect makes Avloclav effective against a wide range of Gram-positive and Gram-negative bacteria.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Amoxicillin: 1 gm – a penicillin-type antibiotic that inhibits bacterial cell wall formation
• Clavulanic Acid: 200 mg – a beta-lactamase inhibitor that enhances the efficacy of amoxicillin

Mechanism of Action

• Amoxicillin: Binds to penicillin-binding proteins (PBPs) in bacteria, preventing cell wall synthesis, leading to bacterial death
• Clavulanic Acid: Inhibits beta-lactamase enzymes, which many bacteria produce to resist amoxicillin
• Provides enhanced antibacterial activity against resistant strains

Indications

Avloclav Injection is indicated for the treatment of:

• Respiratory tract infections (sinusitis, bronchitis, pneumonia)
• Ear, nose, and throat infections (otitis media, tonsillitis, pharyngitis)
• Urinary tract infections (cystitis, pyelonephritis)
• Skin and soft tissue infections
• Bone and joint infections
• Intra-abdominal infections and other infections caused by susceptible bacteria

Dosage and Administration

• Administered via intravenous (IV) infusion or intramuscular (IM) injection as prescribed by a physician
• Typical adult dose: 1 gm + 200 mg every 8–12 hours, depending on infection severity
• Pediatric dosing should be weight-based and determined by a healthcare professional
• Reconstitution and dilution must follow aseptic techniques
• Infuse IV slowly over 20–30 minutes to reduce irritation

Benefits

• Broad-spectrum antibiotic effective against resistant bacterial strains
• Treats a wide range of infections including respiratory, urinary, skin, and abdominal infections
• Reduces risk of treatment failure in beta-lactamase-producing bacterial infections
• Suitable for hospital use for moderate to severe infections

Possible Side Effects

Common side effects:

• Nausea, vomiting, diarrhea
• Mild rash or itching
• Local pain or inflammation at the injection site

Rare but serious side effects:

• Severe allergic reactions (anaphylaxis, swelling, difficulty breathing)
• Liver enzyme elevation or jaundice
• Clostridium difficile-associated diarrhea

Precautions and Warnings

• Contraindicated in patients with penicillin allergy
• Use cautiously in patients with kidney impairment
• Monitor for signs of allergic reaction or severe gastrointestinal symptoms
• Not recommended for viral infections
• Inform your physician of other medications to avoid drug interactions

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• May interact with oral anticoagulants, methotrexate, allopurinol, and other antibiotics
• May reduce effectiveness of oral contraceptives
• Dose adjustment may be required with renal impairment

Storage Instructions

• Store reconstituted injection according to manufacturer instructions
• Keep in a cool, dry place below 25°C
• Protect from light
• Use reconstituted solution immediately or within specified stability period
• Keep out of reach of children.