Avlosef Injection 1 gm/vial contains Cephradine, a first-generation cephalosporin antibiotic used for the treatment of a wide range of bacterial infections. It works by inhibiting bacterial cell wall synthesis, leading to the destruction of susceptible bacteria. This injectable formulation is ideal for moderate to severe infections or when oral administration is not feasible, ensuring rapid and effective antibacterial action.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Cephradine: 1 gm per vial – a cephalosporin antibiotic effective against a variety of bacteria

Mechanism of Action

• Cephradine interferes with the formation of the bacterial cell wall by binding to penicillin-binding proteins (PBPs)
• This action weakens the bacterial structure, causing cell lysis and death
• It is effective mainly against Gram-positive bacteria and some Gram-negative organisms

Indications

Avlosef Injection 1 gm is indicated for the treatment of:

• Respiratory tract infections: bronchitis, pneumonia
• Ear, nose, and throat infections: tonsillitis, pharyngitis
• Urinary tract infections
• Skin and soft tissue infections: cellulitis, abscesses, wound infections
• Bone and joint infections
• Septicemia and severe systemic infections caused by susceptible organisms

Dosage and Administration

• Administered via intravenous (IV) or intramuscular (IM) injection as prescribed by a healthcare professional
• Typical adult dose: 1–4 gm daily in divided doses, depending on severity of infection
• Pediatric dosing is weight-based and determined by the physician
• Reconstitute the vial with appropriate sterile diluent before administration
• Ensure completion of the full course of therapy to prevent resistance

Benefits

• Broad-spectrum antibiotic for effective treatment of various infections
• Suitable for moderate to severe infections requiring injectable therapy
• Provides rapid onset of action
• Effective against common Gram-positive and some Gram-negative bacteria

Possible Side Effects

Common side effects:

• Pain, redness, or swelling at the injection site
• Nausea, vomiting, diarrhea
• Mild rash or itching

Rare but serious side effects:

• Severe allergic reactions (anaphylaxis, swelling, breathing difficulty)
• Antibiotic-associated colitis
• Changes in liver or kidney function

Precautions and Warnings

• Contraindicated in patients with known hypersensitivity to cephalosporins
• Use cautiously in patients with penicillin allergy due to possible cross-reactivity
• Adjust dose in patients with renal impairment
• Monitor for signs of allergic reactions or gastrointestinal complications
• Not effective against viral infections

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• May interact with aminoglycosides and diuretics, increasing risk of kidney toxicity
• Use cautiously with other nephrotoxic drugs
• Inform your physician about all medications being taken

Storage Instructions

• Store below 25°C, protected from light
• Keep the vial in its original packaging until use
• Use reconstituted solution immediately or within recommended time
• Keep out of reach of children.