Cardicor Plus Tablet 2.5 mg+6.5 mg is a combination antihypertensive medication containing Bisoprolol Fumarate 2.5 mg and Hydrochlorothiazide 6.5 mg, designed for effective management of hypertension. By combining a beta-1 selective blocker with a thiazide diuretic, this formulation provides dual-action blood pressure control, addressing both cardiac output and fluid retention.

Bisoprolol works by slowing the heart rate and reducing myocardial contractility, thereby lowering cardiac workload and oxygen demand. Hydrochlorothiazide enhances sodium and water excretion, reducing blood volume and peripheral resistance. Together, these actions provide enhanced antihypertensive efficacy, especially in patients whose blood pressure is not adequately controlled with monotherapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Bisoprolol Fumarate 2.5 mg – selective beta-1 adrenergic receptor blocker

• Hydrochlorothiazide 6.5 mg – thiazide diuretic

Mechanism of Action

Bisoprolol:

• Selectively blocks beta-1 adrenergic receptors in the heart

• Reduces heart rate, cardiac output, and myocardial oxygen demand

• Helps control tachycardia and arrhythmias associated with hypertension

Hydrochlorothiazide:

• Inhibits sodium and chloride reabsorption in the distal tubules of the kidney

• Increases urinary excretion of sodium and water, lowering blood volume

• Reduces peripheral vascular resistance, supporting long-term blood pressure control

The combination of these two mechanisms ensures a complementary and additive effect, improving both hemodynamic and fluid-related factors in hypertension.

Indications

Cardicor Plus Tablet 2.5 mg+6.5 mg is indicated for:

• Essential hypertension, particularly in patients requiring combination therapy

• Hypertensive patients at high cardiovascular risk

• Hypertension with fluid retention

• Heart rate control in patients with elevated heart rate

Benefits

• Enhanced Blood Pressure Reduction: Dual mechanism ensures effective control

• Cardiovascular Protection: Lowers risk of stroke, myocardial infarction, and heart failure

• Relieves Cardiac Stress: Bisoprolol decreases heart rate and workload

• Reduces Fluid Retention: Hydrochlorothiazide decreases blood volume and edema

• Once-Daily Dosing: Convenient and improves patient adherence

• Well-Tolerated: Cardioselective beta-blocker minimizes bronchospastic side effects; low-dose diuretic reduces risk of electrolyte imbalance

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• Adults: 1 tablet orally once daily, preferably at the same time each day

• Can be taken with or without food

• Dose adjustments may be necessary for elderly patients or those with kidney or liver impairment

• Regular monitoring of blood pressure, heart rate, kidney function, and electrolytes is recommended

• Avoid abrupt discontinuation to prevent rebound hypertension or angina exacerbation

Safety and Precautions

• Common side effects: dizziness, fatigue, headache, mild hypotension, increased urination, or cold extremities

• Rare side effects: bradycardia, electrolyte imbalance, severe hypotension, or allergic reactions

• Contraindicated in patients with severe bradycardia, heart block, cardiogenic shock, anuria, or hypersensitivity to either component

• Use cautiously in patients with diabetes, gout, renal impairment, or severe liver disease

• Pregnant and breastfeeding women should use only under medical supervision

• Inform your physician about all concurrent medications to avoid potential drug interactions.