Elacentra Tablet contains Elacestrant 345 mg, an oral selective estrogen receptor degrader (SERD) used for the treatment of hormone receptor (HR)-positive, HER2-negative advanced or metastatic breast cancer. It is indicated in postmenopausal women and adult patients whose disease has progressed after prior endocrine-based therapy.

Elacestrant provides a targeted hormonal treatment option that works directly on estrogen receptors, helping to slow disease progression in endocrine-resistant breast cancer cases. It is administered orally, offering a convenient alternative to injectable endocrine therapies, under strict oncology supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Uses

Elacentra Tablet is prescribed for:

• ER-positive, HER2-negative advanced or metastatic breast cancer
• Patients with disease progression following prior endocrine therapy
• Endocrine-resistant breast cancer (as determined by oncologist evaluation)
• Maintenance and long-term management of hormone-driven breast cancer
• Selected cases based on genetic and biomarker testing (e.g., ESR1 mutations)

Treatment decisions are based on disease stage, prior therapy history, and specialist assessment.

Mechanism of Action

Elacestrant works as a selective estrogen receptor degrader (SERD) through the following actions:

• Binds competitively to estrogen receptors in cancer cells
• Blocks estrogen-mediated signaling pathways that promote tumor growth
• Induces degradation of estrogen receptors
• Reduces proliferation of hormone-dependent cancer cells
• Helps overcome resistance to previous endocrine therapies

By directly targeting estrogen receptor activity, it plays a key role in controlling hormone-sensitive tumor progression.

Dosage & Administration

• Usual dose: as prescribed by an oncologist (commonly once daily oral dosing)
• Should be taken at the same time each day for consistent drug levels
• May be taken with or without food
• Swallow tablet whole with water; do not crush or chew
• Treatment duration depends on response and tolerance
• Regular clinical and laboratory monitoring is required during therapy

Strict adherence to the oncologist’s instructions is essential for optimal outcomes.

Side Effects

Common and clinically observed side effects may include:

• Nausea and vomiting
• Fatigue and weakness
• Decreased appetite
• Hot flashes
• Joint or muscle pain
• Constipation or diarrhea
• Elevated liver enzymes
• Increased cholesterol levels

Most side effects are manageable with supportive care, but ongoing monitoring is important during treatment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Must be used only under oncology specialist supervision
• Not recommended during pregnancy and breastfeeding
• Liver function tests may be required before and during therapy
• Use caution in patients with hepatic impairment
• Inform physician about all concurrent medications to avoid interactions
• Effective contraception is advised during treatment and for a period after discontinuation

Storage

• Store below 25°C in a cool, dry place
• Protect from light and moisture
• Keep in original packaging
• Do not freeze
• Keep out of reach of children.