Inclox 250 mg contains Flucloxacillin, a penicillinase-resistant penicillin designed to combat infections caused by Gram-positive bacteria, including penicillinase-producing staphylococci. This broad-spectrum antibiotic is highly effective against skin, soft tissue, respiratory tract, and other systemic infections. Its bactericidal action, combined with stability against β-lactamases and oral bioavailability, makes it a preferred choice for both prophylactic and therapeutic use in adults and children.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Penicillinase-resistant Penicillins

Indications

Inclox 250 mg is indicated for infections caused by susceptible Gram-positive organisms, including:

Skin and Soft Tissue Infections

• Boils, abscesses, carbuncles

• Eczema, acne, furunculosis, cellulitis

• Infected wounds and burns

Respiratory Tract Infections

• Pneumonia, lung abscesses, empyema

• Sinusitis, pharyngitis, tonsillitis, quinsy

Other Infections

• Osteomyelitis, endocarditis

• Urinary tract infections

• Meningitis, septicaemia

Prophylactic Use

• Used in major surgical procedures, particularly cardiothoracic and orthopedic surgeries, to prevent postoperative infections.

Pharmacology / Mode of Action

Flucloxacillin works by inhibiting bacterial cell wall synthesis, which is essential for bacterial survival. As an isoxazolyl penicillin, it is resistant to penicillinase enzymes produced by certain staphylococci, ensuring its effectiveness against penicillin-resistant strains.

It interferes with peptidoglycan cross-linking in the bacterial cell wall by inhibiting the transpeptidase enzyme. This results in weakened cell walls, swelling, and eventual bacterial lysis. Its acyl side chain prevents β-lactam ring hydrolysis by penicillinase, maintaining its bactericidal activity. Flucloxacillin has limited activity against Gram-negative bacilli.

Dosage and Administration

Oral Administration

• Adults: 250 mg four times daily; may be increased in severe infections

• Osteomyelitis/Endocarditis: Up to 8 g/day in 6–8 hourly divided doses

• Children 2–10 years: Half of adult dose

• Children <2 years: Quarter of adult dose

• Take oral doses 1 hour before meals

Parenteral Administration

• Adults/Elderly: 250 mg four times daily IM; IV 250 mg–1 g four times daily via slow injection or infusion

• Children: Half or quarter of adult dose depending on age

• Severe infections may require doubling the dose

Special Routes

• Intra-articular: 250–500 mg/day in 0.5% lignocaine

• Intrapleural: 250 mg/day

• Nebulization: 125–250 mg in 3 ml sterile water four times daily

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Hypersensitivity to penicillins or flucloxacillin

Side Effects

Common adverse effects include:

• Gastrointestinal: Nausea, vomiting, diarrhea, dyspepsia

• Dermatological: Rash, urticaria, purpura

• Hepatic: Cholestatic jaundice, hepatitis

• Renal: Interstitial nephritis

• Systemic: Fever

Drug Interactions

• Dose adjustments may be necessary in severe renal failure (creatinine clearance <10 ml/min)

Pregnancy and Lactation

• Pregnancy Category B – Use only if clearly necessary

• Excreted in breast milk; caution advised in lactating mothers

Precautions and Warnings

• Use with caution in patients with liver dysfunction or allergic predisposition

• Monitor renal function in severe renal impairment

Storage Conditions

• Store in a cool, dry place away from light and heat

• Keep out of reach of children.