Inducin 10 IU/ml contains Oxytocin, a potent uterotonic drug that acts directly on the smooth muscles of the uterus. It is widely used in obstetric practice to induce labor, stimulate uterine contractions, prevent or treat postpartum hemorrhage, and manage incomplete abortion. Additionally, Inducin may be used under strict medical supervision to stimulate lactation. Its precise, controlled administration ensures effective uterine contractions while minimizing risks to both mother and fetus.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Drugs Acting on the Uterus

Indications

Inducin 10 IU/ml is indicated for:

• Induction of labor: Stimulating uterine contractions when medically necessary.

• Postpartum care: Prevention or treatment of secondary hemorrhage and management of adherent placenta.

• Lactation stimulation: Under guidance of a registered gynecologist or physician.

• Treatment of incomplete or inevitable abortion: Promotes uterine contractions to facilitate rapid expulsion and prevent secondary hemorrhage.

Pharmacology / Mode of Action

Inducin 10 IU/ml works by increasing intracellular calcium levels in uterine smooth muscle cells. This activates myosin light-chain kinase, promoting actomyosin formation and uterine contractions. Oxytocin receptors in the uterine lining increase progressively during pregnancy, peaking during early labor, which allows for stronger and coordinated contractions.

Dosage and Administration

Induction or Stimulation of Labor (IV Infusion)

• Prepare 10 IU in 1000 ml infusion fluid to create a 10 mU/ml solution.

• Start at 0.5–1 mU/min (3–6 ml/hour) and increase by 1–2 mU/min every 30–60 minutes until effective contraction pattern is achieved.

• Once labor progresses to 5–6 cm dilation, reduce dose incrementally.

• Maximum rates rarely exceed 9–10 mU/min at term.

Postpartum Uterine Bleeding (IV/IM)

• Intravenous infusion: 10–40 IU in 1000 ml infusion fluid depending on remaining solution.

• Intramuscular injection: 1–10 IU immediately after delivery of the placenta.

Incomplete or Inevitable Abortion

• IV infusion: 10 IU in 500 ml 0.9% sodium chloride solution.

• IM injection: 2–5 IU every 30–60 minutes as required.

Lactation Stimulation

• Only under professional supervision: 2 IU intramuscularly.

Important: IV administration is preferred; IM injections may cause irregular uterine response.

Contraindications

• Cephalopelvic disproportion, malpositioned fetus, or abnormal fetal presentation

• Overdistended uterus

• Severe toxemia, hypertonic uterine dysfunction

• Fetal distress if delivery is not imminent

• Placenta previa or vasa previa

Side Effects

• Uterine hypertonicity, titanic contractions, or uterine rupture

• Increased blood loss or afibrinogenemia

• Rare: water intoxication with convulsions or coma

• Nausea, vomiting, hemorrhage, cardiac arrhythmias, anaphylaxis

• Neonatal icterus may occur in some cases

Drug Interactions

• Severe hypertension may occur when given with vasoconstrictors during anesthesia

• Cyclopropane anesthesia may cause hypotension or arrhythmias

• Maternal sinus bradycardia and AV conduction abnormalities reported

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use only under continuous medical supervision

• Monitor maternal blood pressure and fetal heart rate

• Use minimal effective dose to achieve desired uterine response

• Exercise caution in patients with uterine or cervical scars

Overdose

Excessive oxytocin may cause violent uterine contractions, fetal bradycardia, uterine rupture, or maternal/fetal death. Immediate discontinuation and tocolytic therapy are recommended.

Pregnancy and Lactation

• Pregnancy Category C: Use only when clearly indicated

• Excretion in human milk is unknown; caution advised

Storage Conditions

• Store at 2–8°C in a dark, frost-free place

• Keep out of reach of children

Reconstitution

• Compatible infusion fluids: 0.9% sodium chloride, 5% dextrose in water, Ringer’s solution, Ringer-lactate

• Ensure thorough mixing and use under controlled conditions.