Intasone Tablet 10 mg contains Hydrocortisone, a synthetic glucocorticoid that mimics the action of the natural hormone cortisol produced by the adrenal glands. It is used in conditions where the body is unable to produce adequate corticosteroids or where suppression of inflammation and immune response is required. Intasone Tablet 10 mg plays an essential role in the management of endocrine disorders, inflammatory diseases, allergic conditions, and autoimmune disorders.

Hydrocortisone is considered a short-acting corticosteroid with both glucocorticoid and mild mineralocorticoid activity, making it particularly useful in replacement therapy for adrenal insufficiency as well as in a wide range of systemic conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Corticosteroids

• Glucocorticoids

Composition

Each tablet contains:

• Hydrocortisone 10 mg

Indications

Intasone Tablet 10 mg is indicated for the treatment and management of the following conditions:

• Primary and secondary adrenal insufficiency (Addison’s disease)

• Congenital adrenal hyperplasia

• Severe allergic conditions, including drug reactions and allergic rhinitis

• Inflammatory and autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus

• Certain dermatological diseases responsive to systemic corticosteroid therapy

• Gastrointestinal disorders including ulcerative colitis and Crohn’s disease

• Respiratory conditions such as bronchial asthma

• Hematological disorders like autoimmune hemolytic anemia

• Adjunct therapy in certain malignancies

Pharmacology

Hydrocortisone acts by binding to intracellular glucocorticoid receptors, resulting in regulation of gene transcription involved in inflammatory and immune responses. It inhibits the formation of inflammatory mediators such as prostaglandins, leukotrienes, and cytokines, thereby reducing inflammation, swelling, and allergic reactions.

Hydrocortisone also influences carbohydrate, protein, and lipid metabolism, helps maintain vascular tone and blood pressure, and supports the body’s physiological response to stress. When administered orally, Intasone Tablet 10 mg provides systemic effects essential for both replacement and anti-inflammatory therapy.

Dosage and Administration

Dosage should be individualized according to the disease being treated and patient response.

Adults:

• Replacement therapy: Usually 15–30 mg daily in divided doses

• Anti-inflammatory or immunosuppressive therapy: Dosage varies depending on severity and clinical condition

Children:

• Dose is adjusted according to body weight and clinical indication and should be determined by a physician

Tablets should be taken with food to minimize gastrointestinal irritation. Long-term therapy requires gradual dose reduction to avoid adrenal suppression.

Contraindications

• Hypersensitivity to hydrocortisone or any component of the formulation

• Systemic fungal infections unless appropriate antifungal treatment is given

Drug Interactions

• Enzyme inducers such as rifampicin and phenytoin may reduce hydrocortisone effectiveness

• Increased risk of gastrointestinal ulceration when used with NSAIDs

• May alter blood glucose control in patients receiving antidiabetic medications

• Increased risk of hypokalemia with certain diuretics

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Possible side effects, especially with prolonged use, include:

• Fluid retention and electrolyte imbalance

• Increased blood pressure

• Hyperglycemia

• Weight gain and mood changes

• Increased susceptibility to infections

Pregnancy and Lactation

Intasone Tablet 10 mg should be used during pregnancy and breastfeeding only when clearly indicated and under medical supervision, weighing potential benefits against possible risks.

Storage Conditions

Store in a cool and dry place, protected from light.
Keep out of reach of children.