Limaryl M Tablet contains a combination of Glimepiride and Metformin, two effective oral antidiabetic agents used in the management of type 2 diabetes mellitus. This lower-strength combination is suitable for patients requiring careful dose initiation or stepwise glycemic control when diet and exercise alone are not sufficient.

The dual mechanism helps achieve better blood sugar control by improving insulin secretion and reducing glucose production in the body.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredients: Glimepiride + Metformin Hydrochloride
• Strength: 1 mg + 500 mg
• Dosage Form: Oral tablet

Mechanism of Action

This combination works through complementary pathways:

Glimepiride:

• Stimulates insulin release from pancreatic beta cells
• Enhances peripheral glucose utilization

Metformin:

• Reduces hepatic glucose production
• Improves insulin sensitivity
• Decreases intestinal absorption of glucose

Together, they provide balanced and effective glycemic control.

Indications

Limaryl M Tablet 1 mg + 500 mg is indicated for:

• Type 2 diabetes mellitus
• Patients inadequately controlled with diet and exercise alone
• Patients requiring low-dose combination therapy
• Step-up therapy when monotherapy is insufficient

Dosage and Administration

• Dose is individualized based on blood glucose levels and medical advice
• Usually taken once or twice daily with meals
• Swallow whole with water
• Do not skip meals to avoid hypoglycemia
• Regular monitoring of blood glucose is recommended

Benefits

• Dual action for improved blood sugar control
• Helps reduce fasting and post-meal glucose levels
• Suitable for initiating combination therapy at low dose
• Reduces pill burden compared to separate medicines
• Supports long-term diabetes management

Side Effects

Common side effects may include:

• Hypoglycemia (low blood sugar)
• Nausea or vomiting
• Diarrhea
• Abdominal discomfort
• Metallic taste
• Headache

Less common but serious effects:

• Lactic acidosis (rare, due to Metformin)
• Weight gain (due to Glimepiride)
• Skin allergic reactions
• Liver enzyme changes

Precautions and Warnings

• Use only under medical supervision
• Risk of hypoglycemia, especially with missed meals
• Avoid excessive alcohol intake
• Caution in kidney or liver impairment
• Monitor renal function and blood glucose regularly
• Temporary discontinuation may be required before surgery or imaging procedures

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Special Populations

• Pregnancy: Insulin is preferred; use only if prescribed
• Lactation: Not recommended unless advised by physician
• Pediatrics: Not routinely recommended
• Elderly: Requires careful monitoring and dose adjustment

Storage

• Store below 25°C
• Protect from moisture and light
• Keep in original packaging
• Keep out of reach of children.