Lopirel Plus Tablet 75 mg+75 mg is a fixed-dose combination of Clopidogrel and Aspirin, two well-established antiplatelet agents widely used in the prevention of thrombotic cardiovascular events. This dual antiplatelet therapy plays a crucial role in reducing the risk of heart attack, stroke, and other serious complications related to abnormal blood clot formation, especially in high-risk patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Clopidogrel 75 mg

• Aspirin 75 mg

Therapeutic Class

Antiplatelet agents (Dual Antiplatelet Therapy)

Indications

Lopirel Plus Tablet is indicated for the prevention of atherothrombotic events in patients with cardiovascular and cerebrovascular diseases, including:

• Acute Coronary Syndrome (ACS), such as unstable angina and non-ST elevation myocardial infarction (NSTEMI)

• Patients with a history of myocardial infarction (heart attack)

• Patients with ischemic stroke or transient ischemic attack (TIA)

• Patients undergoing percutaneous coronary intervention (PCI) with stent placement

• Established peripheral arterial disease

Pharmacology

Clopidogrel is a platelet aggregation inhibitor that works by selectively and irreversibly blocking the P2Y12 ADP receptor on platelet cell membranes. This action prevents platelet activation and aggregation, reducing the formation of blood clots.

Aspirin acts by inhibiting cyclooxygenase-1 (COX-1), which leads to decreased synthesis of thromboxane A2, a potent mediator of platelet aggregation. By combining these two agents, Lopirel Plus provides synergistic antiplatelet effects, offering superior protection against thrombotic events compared to monotherapy.

Dosage and Administration

The dosage of Lopirel Plus Tablet should be determined by a physician based on the patient’s clinical condition. It is generally taken once daily, preferably at the same time each day, with or without food. Patients are advised not to discontinue the medication abruptly without consulting their healthcare provider.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Benefits

• Reduces the risk of heart attack and stroke

• Provides effective dual antiplatelet action

• Improves outcomes in patients with coronary artery disease

• Convenient fixed-dose combination enhances patient compliance

Precautions and Warnings

• Use with caution in patients with bleeding disorders or a history of gastrointestinal bleeding

• Not recommended in patients with hypersensitivity to aspirin, clopidogrel, or other NSAIDs

• Regular monitoring may be required in long-term therapy

• Alcohol consumption should be limited during treatment

Adverse Effects

Common side effects may include gastrointestinal discomfort, bleeding tendencies, bruising, headache, or dizziness. Serious adverse effects are rare but require immediate medical attention.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.