Megatrim DS Tablet is a double-strength oral antibiotic formulation containing Sulphamethoxazole 800 mg and Trimethoprim 160 mg. This fixed-dose combination, widely known as co-trimoxazole, offers broad-spectrum antibacterial activity against a wide range of gram-positive and gram-negative bacteria. Megatrim DS Tablet is commonly prescribed for moderate to severe infections where a higher antibiotic strength is required for effective treatment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Sulphamethoxazole 800 mg

• Trimethoprim 160 mg

• Per film-coated tablet

Therapeutic Class

• Combination antibacterial (Sulfonamide + Folate synthesis inhibitor)

Mechanism of Action

Megatrim DS Tablet works by inhibiting two sequential steps in the bacterial folic acid synthesis pathway. Sulphamethoxazole interferes with the synthesis of dihydrofolic acid by competing with para-aminobenzoic acid, while Trimethoprim inhibits dihydrofolate reductase, preventing the formation of tetrahydrofolic acid. This synergistic mechanism produces a potent bactericidal effect, reducing the risk of bacterial resistance and ensuring effective eradication of susceptible organisms.

Indications

Megatrim DS Tablet is indicated for the treatment of infections caused by sensitive bacteria, including:

• Urinary tract infections

• Respiratory tract infections such as acute bronchitis and pneumonia

• Gastrointestinal infections including traveler’s diarrhea

• Skin and soft tissue infections

• Ear infections such as otitis media

• Certain sexually transmitted infections as advised by a physician

• Pneumocystis jirovecii pneumonia under medical supervision

Dosage and Administration

The dosage and duration of treatment depend on the type and severity of infection, as well as the patient’s age, body weight, and renal function. Megatrim DS Tablet should be taken exactly as prescribed by a healthcare professional. Tablets are usually taken with water and may be taken with food to minimize gastric irritation. Patients are advised to complete the full course of therapy even if symptoms improve earlier.

Precautions and Warnings

• Contraindicated in patients with hypersensitivity to sulfonamides or trimethoprim

• Use with caution in patients with kidney or liver impairment

• Adequate fluid intake is recommended to reduce the risk of crystalluria

• Prolonged use may require monitoring of blood counts

• Should be used during pregnancy and breastfeeding only when clearly indicated and prescribed by a physician

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include nausea, vomiting, diarrhea, loss of appetite, or mild skin rash. Rare but serious adverse effects include severe allergic reactions, blood disorders, or liver dysfunction. Immediate medical attention is advised if severe reactions occur.

Storage

Store Megatrim DS Tablet in a cool and dry place, protected from moisture and direct sunlight. Keep out of reach of children. Do not use after the expiry date printed on the packaging.