Nervalin Capsule 25 mg contains Pregabalin, a proven antiepileptic and neuropathic pain–modulating agent used in the management of several chronic pain conditions and seizure disorders. The 25 mg strength is particularly useful for dose titration, treatment initiation, elderly patients, or individuals with renal impairment who require lower starting doses. Nervalin 25 mg helps relieve nerve-related pain and supports seizure control when used as part of a comprehensive treatment plan under medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Supplemental antiepileptic medications

Indications

Nervalin 25 mg is indicated for the treatment of:

• Neuropathic pain associated with diabetic peripheral neuropathy (DPN)

• Post-herpetic neuralgia (PHN) following shingles

• Adjunctive therapy for partial-onset seizures in patients older than one month

• Fibromyalgia

• Neuropathic pain associated with spinal cord injury

Nervalin 25 mg controlled-release (CR) formulations are additionally indicated for:

• Neuropathic pain due to diabetic peripheral neuropathy

• Post-herpetic neuralgia

Pharmacology

Pregabalin, the active ingredient of Nervalin 25 mg, is a structural analogue of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter. Despite this structural similarity, Pregabalin does not directly bind to GABAA, GABAB, or benzodiazepine receptors. Instead, it binds selectively with high affinity to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding reduces calcium influx into presynaptic neurons, leading to decreased release of excitatory neurotransmitters involved in pain transmission and seizure activity. Nervalin 25 mg has high oral bioavailability of approximately 90%, which is dose-independent, and is eliminated largely unchanged by the kidneys with a mean half-life of about 6.3 hours in patients with normal renal function.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

Dosage should be individualized based on the patient’s condition, response, and renal function.

• Diabetic Peripheral Neuropathy: Treatment usually begins at 150 mg/day in divided doses and may be increased up to 300 mg/day.

• Post-Herpetic Neuralgia: Initial dose is typically 150 mg/day, which may be increased to 300 mg/day within one week. In selected patients, doses up to 600 mg/day may be used.

• Partial-Onset Seizures (Adjunctive Therapy): Starting dose is generally 150 mg/day, with gradual titration up to a maximum of 600 mg/day.

• Fibromyalgia: Recommended dose ranges from 300 to 450 mg/day.

• Neuropathic Pain Associated with Spinal Cord Injury: Dose range is 150 to 600 mg/day.

Nervalin 25 mg capsules can be taken with or without food. Dose adjustment is required in patients with renal impairment. Abrupt discontinuation should be avoided.

Contraindications

Nervalin 25 mg is contraindicated in patients with known hypersensitivity to Pregabalin or any of its excipients.

Side Effects

Common side effects include dizziness, somnolence, dry mouth, blurred vision, peripheral edema, weight gain, and difficulty with concentration or attention. Increased appetite and weight gain may be observed, particularly in pediatric patients treated for seizures.

Pregnancy and Lactation

Nervalin 25 mg is classified as Pregnancy Category C. It should be used during pregnancy only if the potential benefit justifies the possible risk to the fetus. Pregabalin may pass into breast milk; therefore, breastfeeding is generally not recommended unless clearly necessary.

Precautions and Warnings

Caution is advised due to the risk of angioedema, hypersensitivity reactions, suicidal thoughts, respiratory depression when combined with CNS depressants, and dizziness that may impair the ability to drive or operate machinery. Gradual dose tapering over at least two weeks is recommended when discontinuing therapy.

Storage Conditions

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.