Temozar Capsule 250 mg contains Temozolomide 250 mg, an oral alkylating chemotherapeutic agent used in the treatment of malignant brain tumors. It is primarily prescribed for patients with newly diagnosed glioblastoma multiforme and for those with recurrent or refractory anaplastic astrocytoma. Temozar plays a vital role in modern neuro-oncology treatment protocols due to its proven efficacy and ability to penetrate the central nervous system.

Temozolomide is widely recognized for its effectiveness in crossing the blood-brain barrier, making it especially suitable for targeting tumors within the brain. It is often administered alongside radiotherapy during the initial phase of treatment and later continued as maintenance therapy to help control tumor progression.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Temozolomide 250 mg

Mechanism of Action

Temozolomide is a cytotoxic agent that works by damaging the DNA of cancer cells. After oral administration, it is rapidly converted into its active metabolite in the body. This active compound methylates DNA strands, interfering with DNA replication and repair mechanisms. As a result, rapidly dividing tumor cells are unable to multiply and eventually undergo programmed cell death.

Because of its selective activity against rapidly dividing cells, Temozar Capsule is effective in slowing tumor growth and supporting long-term disease management.

Indications

Temozar Capsule 250 mg is indicated for:

• Newly diagnosed glioblastoma multiforme (in combination with radiotherapy followed by maintenance therapy)

• Recurrent or refractory anaplastic astrocytoma

• Other malignant gliomas as directed by an oncology specialist

Treatment should be initiated and monitored by a qualified oncologist experienced in chemotherapy management.

Dosage and Administration

• The dosage is individualized based on body surface area (BSA) and treatment protocol.

• Typically administered once daily in cycles (for example, 5 consecutive days followed by a rest period).

• Capsules should be swallowed whole with water.

• It is advisable to take the medicine on an empty stomach to reduce nausea.

Do not open, crush, or chew the capsule. Follow the prescribed schedule strictly for optimal results.

Benefits

• Effective oral chemotherapy for malignant brain tumors

• Excellent penetration across the blood-brain barrier

• Convenient capsule form for outpatient treatment

• Compatible with radiotherapy protocols

• Helps control tumor progression and improve survival outcomes

Precautions

• Regular monitoring of complete blood count is essential due to the risk of bone marrow suppression.

• Use effective contraception during treatment and for a recommended period afterward.

• Avoid use during pregnancy unless clearly necessary.

• Use with caution in patients with hepatic or renal impairment.

Patients should immediately report symptoms such as fever, unusual bruising, bleeding, or persistent weakness.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects include:

• Nausea and vomiting

• Fatigue

• Loss of appetite

• Constipation

• Headache

Serious side effects may include:

• Neutropenia

• Thrombocytopenia

• Increased risk of infections

Close medical supervision is required throughout therapy.

Storage

• Store below 25°C

• Keep in a dry place away from moisture

• Protect from light

• Keep out of reach of children

Temozar Capsule 250 mg is a trusted chemotherapeutic option designed to support comprehensive brain tumor treatment under specialized medical supervision.