Vastocor 10 mg is a cholesterol-lowering medication containing Vastocor, a statin that helps reduce elevated cholesterol and lipoprotein levels in the blood. It is primarily used to manage hypercholesterolemia and reduce cardiovascular risk in patients with coronary heart disease. By inhibiting HMG-CoA reductase, Vastocor 10 mg promotes the clearance of low-density lipoprotein (LDL) cholesterol and improves overall lipid profiles.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Vastocor 10 mg is indicated for:

• Primary hypercholesterolemia (types IIa and IIb) in patients who do not respond adequately to diet and lifestyle modifications

• Coronary heart disease with elevated plasma cholesterol levels

Therapeutic Class

• Other Anti-anginal & Anti-ischaemic drugs

• Statins (HMG-CoA reductase inhibitors)

Pharmacology / Mode of Action

Vastocor 10 mg reduces LDL cholesterol primarily by inhibiting HMG-CoA reductase, the key enzyme in cholesterol biosynthesis. This inhibition:

• Increases LDL receptor density in liver cells, enhancing LDL removal from plasma

• Promotes catabolism of LDL cholesterol

• Reduces VLDL cholesterol and limits formation of LDL from VLDL

The drug is extensively metabolized in the liver, which is also its main site of action.

Dosage and Administration

• Starting dose: 10 mg once daily in the evening

• Dose adjustment: Every 4 weeks, if needed, up to 40 mg once daily

• Hypercholesterolemia: 5–10 mg daily, max 40 mg

• Coronary heart disease with hypercholesterolemia: Starting dose 20 mg daily in the evening

Special Considerations:

• Patients should maintain a standard cholesterol-lowering diet throughout treatment

• Renal insufficiency does not require dosage adjustment

• Not established for children and adolescents

Drug Interactions

• Digoxin: Slight increase in plasma levels when co-administered

• Warfarin: Slight enhancement of anticoagulant effect

• Other drugs: Generally safe with ACE inhibitors, beta-blockers, calcium channel blockers, diuretics, and NSAIDs

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Active liver disease

• Pregnant or breastfeeding women

• Women of childbearing potential not using effective contraception

• Hypersensitivity to any component of Vastocor

• Homozygous familial hypercholesterolemia with absent LDL receptors

Side Effects

Common side effects include:

• Headache, fatigue, insomnia

• Gastrointestinal issues: nausea, constipation, diarrhea, flatulence, dyspepsia, abdominal cramps

• Muscular effects: myalgia, myositis, myopathy
  Rare cases:

• Rhabdomyolysis with acute renal failure

• Hepatitis, pancreatitis, rash, angioedema

Precautions and Warnings

• Monitor liver function before and during treatment, especially in patients with a history of liver disease or high alcohol intake

• Discontinue if serum transaminase levels rise three times above the upper limit of normal

• Avoid pregnancy during treatment and for one month after discontinuation

Overdose

• No specific antidote available

• General supportive measures and liver function monitoring are recommended

Storage Conditions

• Store in a cool, dry place below 30°C

• Protect from light

• Keep out of reach of children

Pregnancy

• Category X: Contraindicated in pregnancy due to demonstrated fetal risk.