Glipita-M Tablet 50 mg+500 mg is a fixed-dose oral antidiabetic medicine containing Sitagliptin and Metformin Hydrochloride. It is indicated for the management of type 2 diabetes mellitus in adult patients who do not achieve adequate glycemic control with lifestyle modification or monotherapy alone. This combination therapy addresses multiple underlying mechanisms of diabetes, helping maintain stable blood glucose levels throughout the day.

Glipita-M Tablet is suitable for patients who require moderate-dose metformin along with the glucose-dependent action of sitagliptin, offering effective control of both fasting and postprandial blood glucose.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

DPP-4 Inhibitor + Biguanide (Antidiabetic Combination)

Pharmacology

Sitagliptin is a selective dipeptidyl peptidase-4 (DPP-4) inhibitor that increases the levels of active incretin hormones such as GLP-1 and GIP. These hormones enhance glucose-dependent insulin secretion from pancreatic beta cells and suppress glucagon release from alpha cells. This leads to reduced hepatic glucose production and improved glycemic control with a low risk of hypoglycemia.

Metformin Hydrochloride is a biguanide that lowers blood glucose primarily by decreasing hepatic gluconeogenesis, increasing peripheral insulin sensitivity, and reducing intestinal absorption of glucose. Unlike insulin secretagogues, metformin does not stimulate insulin release, making it less likely to cause hypoglycemia.

The combined action of sitagliptin and metformin provides complementary and additive effects, resulting in effective and sustained glucose control.

Indications

Glipita-M Tablet 50 mg+500 mg is indicated for:

• Treatment of type 2 diabetes mellitus in adults

• Patients inadequately controlled on metformin or sitagliptin alone

• Use as adjunct therapy along with diet and exercise

Dosage and Administration

The dosage should be individualized based on the patient’s glycemic response and previous therapy. Glipita-M Tablet is generally taken once or twice daily with meals to minimize gastrointestinal side effects. Treatment should be initiated and adjusted under the guidance of a registered physician.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Benefits and Features

• Dual mechanism of action for comprehensive glycemic control

• Suitable for patients requiring moderate metformin dosage

• Low risk of hypoglycemia when used appropriately

• Controls both fasting and postprandial blood glucose levels

• Well tolerated for long-term diabetes management

Use in Special Populations

• Renal impairment: Use with caution; contraindicated in severe renal dysfunction

• Elderly patients: Regular monitoring of renal function is recommended

• Pregnancy and lactation: Use only if clearly needed and under medical supervision

Side Effects

Common side effects may include:

• Nausea, diarrhea, or abdominal discomfort

• Headache

• Reduced appetite

• Upper respiratory tract infections

Rare but serious adverse effects such as lactic acidosis or pancreatitis require immediate medical attention.

Precautions and Warnings

• Not indicated for type 1 diabetes mellitus or diabetic ketoacidosis

• Periodic monitoring of blood glucose and renal function is essential

• Temporary discontinuation may be necessary before major surgery or contrast imaging procedures

Storage

Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.